Study the Relationship of IFN-γ (+874A/ T) Polymorphism, and Some Cytokines with Breast Cancer in a Population from Baghdad City, Iraq

Background: Breast cancer is still a complicated and common health issue that affects millions of people globally.

Aim: the current investigation aimed to study the relationship of IFN-γ (+874 A/T) genetic polymorphism, and some cytokines to breast cancer women in a population from Baghdad city/ Iraq.

Materials and Methods: In this study, (80) females with an age of (20-60) years were employed; they were attending Oncology Teaching Hospital, Medical City, Baghdad. All these females were notified regarding the purpose of these investigations and agreed to its protocol. 80 healthy women were taken into the current study for comparison purposes.

Results: The findings demonstrated that C3 levels showed a significant (P≤0.05) elevation in patients compared to healthy females. C4 levels demonstrated significantly (P≤0.05) elevation in patients that compared to healthy females. IL-6 levels significantly (P <0.05) increased in patients compared with control group (4.15±0.65 pg/ml). IL-17 concentration in serum of patients showed a significant (P <0.05) increased in patients compared with healthy ones. T and A alleles of IFN-γ T / A +874 locus had distinct results when repeated distribution was used to compare women who had breast cancer to healthy individuals. In the patient BC sample, the T allele was 42.4%, while the allele T in the control group was 71.4%. While the allele A in the sample of BC patients, which is 57.6%, compared to the allele A in control group, which was 28.6%.

Conclusions: This study suggests that elevated IL-6 and IL-17 levels, along with specific IFN-γ gene polymorphisms, could serve as potential biomarkers for breast cancer risk and prognosis.