Efficacy and Safety of Photobiomodulation on Non-infected Pressure Ulcer in Adults: A Study Protocol of Randomized Clinical Trials

Pressure injuries (PIs) are a significant public health issue, causing harm and compromising the safety of hospitalized patients. Some studies suggest that photobiomodulation may promote anti-inflammatory effects and wound revascularization, accelerating the healing process in skin wounds. However, the quality of evidence remains limited. Objective: To evaluate the effectiveness and safety of photobiomodulation as a treatment for non-infected PIs in adults. Methods: It followed the methodological guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA Statement. A systematic search for randomized controlled trials (RCTs) will be conducted in databases from their inception to December 2024 without language restrictions. The databases included MEDLINE, EMBASE, CENTRAL, LILACS, BBO, ICTRP, ClinicalTrials.gov, WHO, and OpenGrey.